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Background: Physical exercise has been long recognized for its therapeutic results on depressive disorders, however the underlying mechanisms remain largely unknown. In the research, we investigated whether or not the bodily train by voluntary wheel running (VWR) alters depression-like behaviors and its impact on mind blood oxygen stage-dependent (Bold) alerts in mice. Ex. The differences in useful brain changes have been determined by Bold practical magnetic resonance imaging (fMRI). Results: The results confirmed that VWR exercise significantly reversed the CUMS-induced behavioral abnormalities. Base on the fMRI amplitude of low-frequency fluctuation (ALFF) evaluation, we discovered that VWR exercise may restore the CUMS-induced extreme Bold activation in parts of limbic system, resembling cortex, hippocampus and corpus callosum. Furthermore, CUMS-induced Bold suppressive areas had been also partially attenuated by VWR train, such as amygdala, cerebellum anterior lobe, thalamus, midbrain, and pontine. Most of those regions are involved in mood-regulating circuit, suggesting dysfunction of the circuit in CUMS mannequin of depression, and VWR train may alter the mood-regulating circuit.